Detection of AZF microdeletions and reproductive hormonal profile analysis of infertile sudanese men pursuing assisted reproductive approaches
نویسندگان
چکیده
منابع مشابه
Detection of Y Chromosome Microdeletions and Hormonal Profile Analysis of Infertile Men undergoing Assisted Reproductive Technologies
Objective Y chromosome deletions (YCDs) in azoospermia factor (AZF) region are associated with abnormal spermatogenesis and may lead to azoospermia or severe oligozoospermia. Assisted reproductive technologies (ART) by intracytoplasmic sperm injection (ICSI) and testicular sperm extraction (TESE) are commonly required for infertility management of patients carrying YCDs. The aim of this study w...
متن کاملTracking microdeletions of the AZF region in a patrilineal line of infertile men.
Male infertility is considered to be a difficult-to-treat condition because it is not a single entity, but rather reflects a variety of different pathologic conditions, thus making it difficult to use a single treatment strategy. Structural alterations in the Y chromosome have been the principal factor responsible for male infertility. We examined 26 family members of 13 patients with male infe...
متن کاملبررسی مولکولی حذف‌های کروموزوم Y در نواحی AZF بیماران مبتلا به آزواسپرمی و اولیگواسپرمی غیر انسدادی مراجعه‌کننده به مرکز ناباروری منتصریه مشهد
Background and Aim: The Y-chromosome azoospermic factor (AZF) regions consist of genes whose specific roles and functions in spermatogenesis and fertility have not been completely clarified. Hence, recognition of the association between AZF microdeletions and male infertility has suggestions for the diagnosis, treatment, and genetic counseling. The main objective of the present study was invest...
متن کاملCytogenetic abnormalities and azoospermia factor (AZF) microdeletions in infertile men from Kuwait
Approximately 15% of couples in the reproductive age group worldwide are affected by infertility, and it is estimated that about 40-50% of infertilities are of male origin. Genetic factor accounts for 10-15% of severe male infertility, including chromosomal aberrations and single gene mutations (Ferlin et al, 2006). After the Klinfelter syndrome, Y chromosomal microdeletions are the most freque...
متن کاملDetection of Partial AZFc Microdeletions in Azoospermic Infertile Men Is Not Informative of MicroTESE Outcome
Objective microdeletions of Yq chromosome are the most frequent molecular genetics etiology for the male infertility which usually spans AZFa (azoo spermia factor a), AZFb and AZFc regions. Microdeletions are mostly seen in AZFc region and usually cover genes actively involved in spermatogenesis. Partial AZFc microdeletion may also happen with various spans namely gr/gr, b2/b3 and b1/b3. It is ...
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ژورنال
عنوان ژورنال: BMC Urology
سال: 2021
ISSN: 1471-2490
DOI: 10.1186/s12894-021-00834-3